ULBPs: regulators of human lymphocyte stress recognition

ULBPs: regulators of human lymphocyte stress recognition

NKG2D is a critical activatory molecule expressed on cytotoxic cells such as NK cells, γδ T cells and subsets of αβ T cells [1]. Ligation of NKG2D acts to trigger cytotoxicity of NK cells and acts as a co-stimulatory molecule on T cells. The ligands that bind to NKG2D, known as NKG2DL, are grouped into two families and comprise eight different proteins termed MIC-A/B and ULBP1-6 (Figure 1a). Im...

Microangiectasias: structural regulators of lymphocyte transmigration.

The migration of lymphocytes into inflammatory tissue requires the migrating cell to overcome mechanical forces produced by blood flow. A generally accepted hypothesis is that these forces are overcome by a multistep sequence of adhesive interactions between lymphocytes and endothelial cells. This hypothesis has been recently challenged by results demonstrating wall shear stress on the order of...

Radioadaptive Response in Human Lymphocyte Cells

The adaptive response (AR) is a phenomenon by which cells exposure to sublethal doses of DNA-damaging agents (non-mutagenic dose of chemical or radiation), known as conditioning treatment (CT), leads to increased resistance to a subsequent exposure to a higher dose of the same or other agents, known as challenge treatment (CR). The adaptive response (AR) induced by radiation in human lymphocyte...

The effect of oxidant stress on human lymphocyte cytotoxicity.

We have studied the effect of oxidant stress on human lymphocyte cytotoxicity. Lymphocyte cultures maintained good viability after incubation with xanthine and xanthine oxidase. an enzyme system known to generate several highly reactive oxygen compounds. We demonstrated that these lymphocytes were viable after exposure to an in vitro oxidant stress but had a significant impairment in both antib...

Human T lymphocyte subsets. Functional heterogeneity and surface recognition structures.